Radiolabeled bronchodilators (fill volume of 3 mL: 0.5 mL salbutamol 2.5 mg + 0.125 mL ipratropium 0.25 mg and physiologic saline up to 3 mL) were delivered until sputtering during NIV (pressures of 12 cmH2O and 5 cmH2O - inspiratory and expiratory, respectively) using an oro-nasal facemask. To compare pulmonary deposition and distribution across regions of interest with administration of radiolabeled aerosols generated by vibrating mesh nebulizers (VMN) and jet nebulizer (JN) during NIV.Ī crossover single dose study involving 9 stable subjects with moderate to severe COPD randomly allocated to receive aerosol administration by the VMN Aerogen and the MistyNeb jet nebulizer operating with oxygen at 8 lpm during NIV. Electronic address: effects from non-invasive ventilation (NIV) in acute COPD are well-established, but the impact of nebulization during NIV has not been well described. Electronic address: 7 Department of Physicaltherapy, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address: 6 Division of Respiratory Care, Rush Medical School, Chicago, IL, USA. Electronic address: 5 Department of Nuclear Medicine, Hospital Das Clínicas de Pernambuco, Recife, Pernambuco, Brazil. Electronic address: 4 Department of Physicaltherapy, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address: 3 Department of Physicaltherapy, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address: 2 Department of Physicaltherapy, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. 1 Department of Physicaltherapy, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

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